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Graphpad prism heatmap7/8/2023 Finally, gene expression data from AsA SLE patients corroborated the molecular pathways predicted by SNP associations. An independent dataset derived from summary genome-wide association data in an AsA cohort was interrogated and identified similar molecular pathways. SLE-associated pathways in AsA patients included elevated oxidative stress, altered metabolism and mitochondrial dysfunction, whereas SLE-associated pathways in EA patients included a robust interferon response (type I and II) related to enhanced cytosolic nucleic acid sensing and signaling. ![]() Genetic associations were examined using connectivity mapping and gene signatures based on predicted biological pathways and were used to interrogate gene expression datasets. We identified 2778 ancestry-specific and 327 trans-ancestry SLE-risk polymorphisms. Here, we utilized available gene expression data and genotype data based on all non-HLA SNP associations in EA and AsA SLE patients detected using the Immunochip genotyping array. However, the mechanisms underlying elevated severity in the AsA population remain unclear. Individuals of Asian-Ancestry (AsA) disproportionately experience more severe SLE compared to individuals of European-Ancestry (EA), including increased renal involvement and tissue damage. ![]() ![]() Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disorder with a prominent genetic component.
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